Effect of Raspberry on Osteoporosis Model in Ovariectomized Rats

Ming-San MIAO, Hui ZHAO, Meng-Fei ZHANG

Abstract


Objective: To investigate the effects of raspberry on various indexes of serum and urine and bone mineral density in rats with osteoporosis. Methods: Female ovariectomized osteoporosis animal model was established by ovariectomy. Rats were completely removed the left ovary, the right removal of 80%, after careful breeding, intramuscular injection of penicillin 800000 u / kg (each 0.1ml) to prevent infection, continuous 3d, 1 day. After that, except for the model blank group, the rats in each group were given gavage for 60 days. The rats in the blank group were given the same amount of normal saline. The rats were fasted on the 58th day, Urine was taken 2h after the last administration on the 60th day. Blood was taken from the eye and the serum was separated. Serum calcium (Ca), phosphorus (P), serum BGP, urinary calcium, phosphorus, creatinine (Cr) and hydroxyproline (HYP) were measured. The tibias on one side of femur on both sides of the rats were used for bone mineral density,
pathological examination and biomechanical measurement. Results: Compared with the blank group, serum Ca in the model group decreased significantly. High-dose raspberry group and Xianlinggubao group could significantly reduce the level of serum Ca, and middle-dose raspberry group also decreased serum Ca. Conclusion: The raspberry high, medium and low dose groups have a good intervention on osteoporosis model in ovariectomized rats.


Keywords


Osteoporosis, Mouse, Raspberry


DOI
10.12783/dtbh/icmsb2018/25457

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