Docking Studies on a Series of Polo-like Kinase 4 Inhibitors

Ru DING, Juan LIU, Rong TAN, Yuan LIU, Ping YI

Abstract


Polo-like kinase 4 (PLK4), a mitotic kinase was regarded as a potential target for cancer therapy. a novel series of PLK4 competitive kinase inhibitors have been docked into the active site of Polo-like kinase 4 (PDB code 4JXF) by using CCDC GOLD, furthermore, the binding modes for the inhibitors generated by MOE2015 may explain the mechanism of kinase selectivity.

Keywords


Polo-like kinase 4, Dock, Inhibitor


DOI
10.12783/dtbh/icmsb2018/25447

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