Pharmacokinetic Profile of Calceolarioside A Administration to Mice

GANG XUE, YU-JUAN CHEN, XIANG-NAN MENG, CHENG-HONG MA

Abstract


Calceolarioside A has a potential effect of anti-food allergy, which was isolated from the bark of Fraxinus mandshurica Rupr. In this article, to study the pharmacokinetic of Calceolarioside A in mice, HPLC was used to determine it in the mice serum at different time after oral administration of Calceolarioside A (group A) and butanol extract (group B, contain the same concentration of Calceolarioside A). The Pharmacokinetic parameters were analyzed by PK-solver. As the results showed, the Cmax was 661.19±104.07 ng/mL, Tmax was 1h, AUC0-t was 1958.76±442.18 ng/mL·h, T1/2 was 4.46±0.79 h in group A. And in group B, the Cmax, Tmax, AUC0-t and T1/2 were 1624.92±702.35 ng/mL, 1h, 5854.52±1596.86 ng/mL·h, 2.81±0.65 h, respectively. In conclusion, this method is successfully applied in the pharmacokinetic profile of Calceolarioside A in mice serum.

Keywords


Pharmacokinetic, Calceolarioside A, Mouse, Serum.


DOI
10.12783/dtbh/icmsb2017/17973

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