Analysis of Endogenous Antioxidant Peptides and Oxidative Stress Levels in Diabetic Cardiomyopathy

XIAO-DAN QI, LING-FENG CHANG, QI WU, YONG GAO, SHU-DONG LIN, CHUN-JING ZHANG, HAI-TAO YU, XIAO-GUANG YAN, DONG-XIA XU

Abstract


To investigate endogenous carnosine, glutathione system and oxidative stress levels in serum of patients with diabetic cardiomyopathy, and analyze relationships among endogenous carnosine, glutathione system and oxidative stress of patients with diabetic cardiomyopathy. The serum of 68 healthy people (NC), 75 patients with type 2 diabetes mellitus (DM) and 57 patients with diabetic cardiomyopathy (DCM) of the third affiliated hospital of QiQihar Medical University were collected. Carnosine content was measured by ELISA. T-GSH, GSH and GSSG were measured by micro-enzyme labeling. Clinical datas were compared: In comparison to NC group, BMI, FPG, 2hPG,C peptide and HbA1c in the DCM group and DM group increased significantly (P<0.05). The average value of human serum carnosine content, GSH content, GSH/GSSG ratio in the DM and DCM group were significantly lower than that in the control one (P<0.05). Serum endogenous antioxidant peptides and reduced glutathione (GSH) level drop and the imbalance of redox state in diabetic cardiomyopathy patients, which promote the occurrence and development of diabetic cardiomyopathy.

Keywords


Diabetic cardiomyopathy, Carnosine, Glutathione system, Oxidative stress.


DOI
10.12783/dtbh/icmsb2017/17955

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